Some refer to us as the best kept secret...
other use the high precision MMI laser microdissection technology to come up with exciting results in biomedical research and biomarker discovery.
Take notice of the following publications...
Laser microdissection uses a highly focused laser beam technology to facilitate the isolation of specific cell populations from a heterogeneous tissue sample under microscopic observation. The fact that around 400 research papers are published in well known medical and scientific journals each year, emphasizes its increasing importance and usage. Not only specific scientific questions are addressed by means of laser microdissection, but also significant discoveries in biomedical research disciplines are being made. To name a few, the molecular profiling of pure cell populations in cancer research, neurology (Parkinsons, Alzheimer's), immunology (Rheumatism, Auto-immune diseases), dermatology, and in cardiology.
In his current work, Ronald Buckanovic's group at the Center for Research on Reproduction and Woman's health at the University of Pennsylvania introduced and established the use of immuno-laser microdissection (Buckanovich et al., 2006 Buchanovich et al., 2007). With the aim to identify novel ovarian cancer biomarkers, his group investigated the expression profiles of tumor versus healthy ovarian vascular cells that were microdissected with the MMI CapLift technology. By establishing genome-wide transcriptional profiling after immuno-laser microdissection, they identified the molecular profile of ovarian tumor vasculature. Specifically, they were able to identify 12 novel ovarian biomarkers, one of which is associated with decreased disease-free interval....
Buckanovich, R.J., Sasaroli, D., O'Brien-Jenkins, A., Botbyl, J., Conejo-Garcia, J.R., Benecia, F., Liotta, L.A., Gimotty, P.A., and Coukos, G. (2006). Use of immuno-LCM to identify the in situ expression profile of cellular constituents of the tumor microenvironment. Cancer Biol. Ther. 5, 635-642. Buckanovich, R.J., Sasaroli, D., O'Brien-Jenkins, A., Botbyl, J., Hammond, R., Katsaros, D., Sandaltzopoulos, R., Liotta, L.A., Gimotty, P.A., and Coukos, G. (2007). Tumor vascular proteins as biomarkers in ovarian cancer. J. Clin. Oncol. 25, 852-861
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