Molecular Machines & Industries

Developmental biology in 4D

In developmental biology, many processes are not yet fully understood as the regulatory network and interplay of development-related transcription factors is very complex.

The study published by Cui et al. incorporated time as an additional dimension to 3D Geo-Seq data to uncover transcription factor activity at key developmental timepoints in germ layer specification and lineage differentiation.

The analysis of the spatial transcriptome of development-related transcription factors generated a series of molecular maps that depicted the developmental trajectory of four major progenitor populations during gastrulation that was not previously identified by conventional fate mapping.

Read the full publication here

We use cookies on this website to analyze traffic and optimize your user experience. Detailed information on how this analysis works can be found in our Privacy Policy.