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Precise Isolation of Colonies and Rare Cells in Suspension
The MMI CellEctor cell picker is an essential tool for the precise isolation and examination of individual cells, particularly when only limited cell numbers are available. Fluorescent cell sorters often fail to preserve every cell, which can be problematic when rare cells are of interest. For example, circulating tumour cells (CTCs) are extremely scarce, making conventional sorting approaches potentially inefficient or overly harsh. The CellEctor enables the gentle and selective isolation of rare single cells, as well as small cell clusters, such as spheroids, directly from suspension without exposing them to harsh treatment.
CellEctor is a high-precision microfluidic cell picking robot designed for gentle cell transfer with the highest cell integrity and growth rates after cell transfer. This microfluidic robot works with nanoliter volumes and has up to 100% picking/transfer efficiency of living or fixed cells. You can further automate the selection of cells with our advanced AI Software, CellDetector, allowing for precision in both fluorescence and brightfield while improving your throughput.
The cell picker is compatible with a wide range of slide-based platforms including PCR tubes, IBIDI, Sievewell nanowells and well plate formats (e.g. 96-well plate). It is also compatible with most inverted microscopes and fully expandable with all other MMI solutions: Laser microdissection (CellCut), whole slide imaging (CellScan) and optical trapping (CellManipulator).
Cell picking with the MMI CellEctor gives users complete control over manual and automated cell identification, acquisition, and deposition. The cell picking process is contamination-free and supports a broad range of sample types.
Target cells manually or automatically.
The glass capillary aspirates the cell of interest.
Deposit your cells onto various slide platforms.
After cell picking, cells are ready for downstream applications.
Update the CellEctor cell picker with the MMI CellDetector. The CellDetector is an AI-powered analysis software that automatically identifies rare cells in any sample by evaluating their colour (fluorescence), morphology, and relative size. Automated detection with CellDetector removes the need for labour-intensive manual searching, ensuring maximum efficiency and reproducibility in your workflow.
The MMI CellEctor cell picker is widely used for a range of applications, including the isolation of rare & single cells:
Compatible with leading inverted microscope brands
MMI CellEctor cell picker is compatible with almost all inverted microscopes
Supports all imaging modes and objectives
CellEctor supports a wide range of imaging modes and microscope objectives.
Combine with an incubation hood
For live-cell workflows, the CellEctor cell picker can be integrated into an incubation hood, ensuring optimal environmental conditions.
Fully compatible with all MMI single-cell solutions
CellEctor is fully compatible with all MMI single-cell solutions and can be expanded with a whole-slide scanner (CellScan), an LMD system (CellCut), and optical tweezers (CellManipulator) to support advanced single-cell research and future experimental requirements.
The CellEctor gives you the ability to work in nanoliters of volume. The system gives you full control of how to pump in and out to acquire your sample of interest.
The CellEctor can capture, dispense and do a rinse step well under a minute. However, it is best to note that the CellEctor is not a high-throughput system. Rather, it is a highly efficient and exact system to collect a rare cell sample gently in order to ensure its survival.
You can collect as many cells as you like (one by one).
With CellEctor cell picker you have the ability to isolate adherent cells with the “Shake Mode”. This mode brings down the capillary and uses it to gently pull the adherent cell off the surface by use of circular motions.
After each aspiration, you can rinse the capillary in a solution of your choice. The CellEctor cell pciers liquid-handling workflow is flexible, allowing you to add rinsing steps whenever needed.
The capillaries used for the CellEctor cell picker come in a wide variety of sizes, ranging from 10 µm to 160 µm.
The MMI CellEctor allows researchers to isolate and manipulate desired cells without the need for complex sorting techniques like Fluorescence-Activated Cell Sorting (FACS). While FACS is efficient for high-throughput sorting based on specific markers, it may not be suitable for certain applications where the target cells are rare or require more precise selection. In such cases, cell picking with the MMI CellEctor provides a viable alternative, enabling researchers to manually choose and collect individual cells of interest.
A cell picker is an automated system used to select and isolate individual cells from a heterogeneous population. Cell picking is performed for various tasks such as cell sorting and single-cell analysis (e.g. single cell genomics to understand cellular heterogeneity and gene expression at the single cell level). The use of a cell picker has significantly advanced the field of cell biology and contributed to breakthroughs in various areas of research, such as cancer biology, stem cell research, and immunology, by enabling more precise and targeted analyses at the single cell level.
The MMI CellEctor cell picking system automates the cell pickup process using a microscope-based micro-capillary sorting system. The highly precise nanoliter pump enables single cell isolation even in nanoliter volumes. Since the system is fully motorised and computer-controlled, it offers complete control in manual and automated cell recognition, acquisition and deposition modes.