MMI just installed CellManipulator at Cambridge University

MMI just installed the CellManipulator at Cambridge University, specifically within the research group led by Dr. Bakshi. The group’s focus is to uncover the genetic and metabolic regulatory systems underlying the emergence of antibiotic resistance in bacteria. In their research, the ability to perform time-resolved single-cell phenotyping followed by genotyping is of paramount importance. They have devised an exceptionally high-throughput microfluidic platform capable of tracking over a hundred-thousand individual cell lineages within a spatio-temporally uniform growth environment. With time-resolved microscopy and machine learning techniques, they have gained insights into the dynamic responses of individual cells to antibiotic treatments. Moreover, they are adept at correlating these responses with the unique physiological histories of each cell.

In their upcoming research phase, the group aims to link the physiological heterogeneities to the underlying genetic. For this reason, they will employ MMI CellManipulator Optical Tweezers to isolate individual cells after screening, facilitating subsequent genotyping. This genotype – phenotype correlation promises a thorough comprehension of the mechanisms governing bacterial response to antibiotics. Furthermore, it opens new paths for therapy development.

Responding to Dr. Bakhsi’s needs, MMI provided him with a customized Optical Tweezers system to support the automation the retrieval process. Indeed, it exemplifies our commitment to aiding customers in accelerating research and achieving groundbreaking results across diverse fields. Through our steadfast commitment to innovation and excellence, we empower scientists worldwide to unravel the mysteries of single-cell biology and catalyze transformative discoveries.