Automated Laser Microdissection (LMD) for Spatial Omics Research
Spatial omics research is crucial for understanding the spatial organization of biological molecules, providing key insights into cellular function and disease mechanisms. To ensure applicability to large patient cohorts and low sample inputs, including single-cell applications, an automated and high-throughput sample preparation and isolation protocol is crucial. By integrating artificial intelligence (AI) with automated high-throughput laser microdissection (LMD) and mass spectrometry, these demands are effectively met.
Automated LMD Solution by MMI: CellCut + CellRobot
MMI’s automated LMD solution combines the precision of the CellCut Laser Microdissection system with the efficiency of the CellRobot. This powerful integration enables the fully automated isolation of hundreds of cells in each well of a 96-well plate — delivering high-throughput performance with unmatched accuracy and consistency.


We appreciate the resistant MMI product quality, the professional consulting, and the competent and quick service. MMI instruments are an important basis for our in-situ analysis of cellular tissue. The MMI CellCut laser microdissection for cell isolation followed by gene expression analysis is complementary to further routine methods like conventional optical microscopy (fluorescence), in-situ hybridization, and immunohistochemistry.
CellCut achieves a 100% success rate in single cell and subcellular collection, helping us discover new immunosuppressive cell subtypes in pancreatic cancer, with significant publications forthcoming.
URWTH Aachen, Germany

“I have compared all current available LMD platforms thoroughly and I got to say the CellCut plus is the most impressive one and I highly recommend it to our colleagues. Thanks for bring it to me.”
Chinese Academy of Sciences
Guangzhou, China



Our team at the University of Utah had the opportunity to trial the CellCut system, and the results were immediately impressive. The DNA yield exceeded expectations, outperforming our previous protocol. The CellCut system offered unparalleled precision, using direct „no failure“ capture for complete sample recovery, unlike the Zeiss system’s crypt chunk catapulting. Its gentler laser minimized DNA damage and the silicone-based capture simplified sample transfer.
We were able to prepare 16 successful whole genome sequencing libraries faster than a single capture-to-DNA extraction trial with the Zeiss, where results consistently failed. I am confident the CellCut system will be an invaluable resource for the Human Genetics Department and other research groups at the University of Utah, significantly enhancing both efficiency and outcomes.
University of Utah, Salt Lake City, USA

"Our experience for cell isolation with MMI CellCut has been overwhelmingly positive. Its flexibility and user-friendly interface allowed seamless integration of diverse imaging and proteomic data, enhancing our analysis of tumor and neural heterogeneity.
CellCut achieves a 100% success rate in single cell and subcellular collection, helping us discover new immunosuppressive cell subtypes in pancreatic cancer, with significant publications forthcoming."
Shenzhen, China